| Acanthosis Nigricans AN is observed in 74% of patients with obesity. This is explained by the findings that obese patients have higher levels of insulin than people who are not obese. Obese children, as well as individuals of Native American or African-American descent, have a higher incidence of AN. AN is due to cellular insulin resistance, increased insulin production, stimulation of IGF receptors by insulin and IGF receptor induction of keratinocyte proliferation. This results in a thickening of the skin. The relative velvety darkness on the neck, on the axilla, and under the breasts is due to hyperkeratosis. |
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| Aesthetic Medicine Today |
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