Bovine collagen

Bovine collagen dermal fillers contain 95% type I bovine collagen and 5% type III
bovine collagen.  Because bovine collagen protein is different from human collagen,
an allergic reactions have been reported.  The incidence of an allergic reaction is
reportedly at 3%.  

Therefore, 2 skin tests must be performed prior to treatment. The first test should be
performed at least 6 weeks prior to treatment, followed by a second test 4 weeks
later.  At least 2 weeks should elapse after the second skin test before treatment can
ensue.  This process is repeated before each injection cycle.
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