| Hyaluronic Acid Hyaluronic acid is the most prominent glycosaminoglycan in the skin. Hyaluronic acid potently binds to water with studies revealing on a volume basis that hyalurinic acid draws 1000 drops of water to one drop of hyaluronic acid. Thus when injected into a rhytide or volume depleted areas, patients will notice that the hyaluronic acid will volumize, soften, and hydrate the skin. In addition to these benefits, it plays a role in cell growth, membrane receptor function, and adhesion. Biochemically, hyaluronic acid stabilizes intercellular structures and produces the viscoelastic network for collagen and elastin fibers to bind together. In February 2003, the FDA approved Restylane, a cross-linked, nonanimal source hyaluronic acid. This dermal filler was quickly embraced when found to be:
Restylane Restylane was approved by the FDA in 2003 for the treatment of nasolabial folds. This dermal filler is used for correction of the nasolabial folds, marionette lines, and glabellar frown lines, in addition to lip enhancement and cheek augmentation. Other clinical uses include correction of the jowls and nasal deformities. In general, most patients can expect 6 - 9 months of correction. Perlane This dermal filler is identical to Restylane except that it consists of larger gel particles. This dermal filler is suitable for the correction of deeper folds, such as the nasolabial folds, and works well for cheek enhancement. Additionally, some experienced physicians prefer this dermal filler for lip augmentation over Restylane. Most patients can expect 6-12 months of correction with Perlane. Editor's Note: I have noted that many of my patients experienced satisfactory clinical results lasting upto 24 months after the second injection given at 9 months. Juvederm (Juvederm Ultra/Juvederm Ultra Plus) In 2006, the FDA approved Juvederm, which is also a nonanimal stabilized hyaluronic dermal filler. Juvederm Ultra Plus has a higher proportion of cross-linking than Juvederm Ultra. Juvederm is a homologous gel with the highest degree of cross- linking of any of the hyaluronic acid fillers and thus has a smooth consistency. Juvederm Ultra and Juvederm Ultra Plus have indications similar to those of Restylane and Perlane, respectively, and do not require skin tests prior to use. Hyaluronic Acid Precautions The adverse effects are: discomfort with injection, erythema, swelling, and bruising. If injected too superficially a bluish Tyndall effect, and nodules may appear. |
| Hyaluronic Acid Hyaluronic acid is the most prominent glycosaminoglycan in the skin. Hyaluronic acid potently binds to water with studies revealing on a volume basis that hyalurinic acid draws 1000 drops of water to one drop of hyaluronic acid. Thus when injected into a rhytide or volume depleted areas, patients will notice that the hyaluronic acid will volumize, soften, and hydrate the skin. In addition to these benefits, it plays a role in cell growth, membrane receptor function, and adhesion. Biochemically, hyaluronic acid stabilizes intercellular structures and produces the viscoelastic network for collagen and elastin fibers to bind together. In February 2003, the FDA approved Restylane, a cross-linked, nonanimal source hyaluronic acid. This dermal filler was quickly embraced when found to be:
Restylane Restylane was approved by the FDA in 2003 for the treatment of nasolabial folds. This dermal filler is used for correction of the nasolabial folds, marionette lines, and glabellar frown lines, in addition to lip enhancement and cheek augmentation. Other clinical uses include correction of the jowls and nasal deformities. In general, most patients can expect 6 - 9 months of correction. Perlane This dermal filler is identical to Restylane except that it consists of larger gel particles. This dermal filler is suitable for the correction of deeper folds, such as the nasolabial folds, and works well for cheek enhancement. Additionally, some experienced physicians prefer this dermal filler for lip augmentation over Restylane. Most patients can expect 6-12 months of correction with Perlane. Editor's Note: I have noted that many of my patients experienced satisfactory clinical results lasting upto 24 months after the second injection given at 9 months. Juvederm (Juvederm Ultra/Juvederm Ultra Plus) In 2006, the FDA approved Juvederm, which is also a nonanimal stabilized hyaluronic dermal filler. Juvederm Ultra Plus has a higher proportion of cross-linking than Juvederm Ultra. Juvederm is a homologous gel with the highest degree of cross- linking of any of the hyaluronic acid fillers and thus has a smooth consistency. Juvederm Ultra and Juvederm Ultra Plus have indications similar to those of Restylane and Perlane, respectively, and do not require skin tests prior to use. Hyaluronic Acid Precautions The adverse effects are: discomfort with injection, erythema, swelling, and bruising. If injected too superficially a bluish Tyndall effect, and nodules may appear. |
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| Aesthetic Medicine Today |
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